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  • Custom Synthetic COFs

    Custom Synthetic COFs

    Alfa Chemistry provides custom synthesis service for a variety of COFs. The unique properties of COFs have motivated their applications in a wide range of fields. To further stimulate their application potential, more and more COFs with excellent properties are need to be designed and synthesized. In addition, the design and discovery of novel COFs can service great contribution to the development of materials science. Alfa Chemistry has been committed to the research and development of crystalline porous materials since its establishment. Our chemists have extensive experience in the preparation and analysis of COFs and we can provide customized COFs quickly and efficiently based upon your specifications and project needs. Alfa Chemistry will very proud to provide you with the quality products and services you have come to expect. Contact us now.

    Our Services

    • Custom options

    Alfa Chemistry has the ability to customize synthetic various types of COFs. According to the building units, we can provide custom COFs including but not limited to the following:

    • Borates-based COFs
    • Imines-based COFs
    • Ketones\enamines-based COFs
    • Phthalocyanines-based COFs
    • etc.
    • Triazines-based COFs
    • Phenylhydrazones-based COFs
    • Polyimides-based COFs
    • Porphyrins-based COFs

    According to the structural features, we can provide custom 2D COFs and 3D COFs. The 2D COFs include but not limited to the following:

    • Hexagonal COFs
    • Tetragonal COFs
    • Rhombic COFs
    • etc.
    • Kagome COFs
    • Triangular COFs
    • Heteropore COFs

    Examples of 2D COFs with different structures.Fig. 1. Examples of 2D COFs with different structures [1].

    • Product delivery

    Upon completion of the project, in addition to delivering the target COFs product, we will provide experimental data related to the target COFs, including synthetic records (synthetic original record) and characterization analysis data (single crystal X-ray diffraction (SXRD), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) spectroscopy, scanning electron microscope (SEM), transmission electron microscopy (TEM), nitrogen adsorption etc.).

    Synthesis Methods

    Finding a suitable synthetic method for the COFs synthesis is by no means a trivial issue. Herein, we introduce the solvothermal, microwave, interfacial and room-temperature methods applied for the COFs synthesis that are frequently used in our company.

    • Solvothermal synthesis: Solvothermal synthesis method is the most common method for COFs synthesis. The solvothermal synthesis of COFs often takes 2 to 9 days and requires heating (80–120 °C) within a sealed vessel. Moreover, the reaction time, temperature, solvent conditions, and catalyst concentration are the most important factors to be considered in preparing crystalline porous COFs by this method.
    • Microwave synthesis: Microwave synthesis allows the synthetic process of COFs to be completed in a faster and cleaner manner. A general microwave method is described as follows. A mixture of monomers in a suitable solvent is sealed in a microwave tube under nitrogen or vacuum and heated with stirring for 60 min at a designated temperature, such as 100 °C.

    Microwave synthesis apparatus.Fig. 2. Microwave synthesis apparatus.

    • Interfacial synthesis: The interfacial synthetic strategy is a novel and efficient method for fabricating COFs films with simultaneous control of their thickness. This method enables the production of films with a tunable thickness from 4 to 150 nm.
    • Room-temperature synthesis: By avoiding both the use of sealed vessels and the difficulty in controlling different synthetic parameters, the synthesis of COFs at room temperature is attractive, especially for cases of fragile building blocks or sensitive substrates.

    Customer Order Process

    Customer Order Process


    1. Geng K., et al. Covalent organic frameworks: design, synthesis, and functions[J]. Chemical reviews, 2020, 120(16): 8814-8933.

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