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Developments in biomedical imaging enables the visualization, evaluation, and quantification of biological processes at the molecular and cellular levels in a noninvasive means, and shows great potential in the earlier diagnosis of diseases, on-going assessment of treatments, and optimization of disease therapeutic protocols, greatly encouraging the diagnosis of diseases. Imaging agents, such as fluorescent small molecules and imaging contrast agents are the core and foundation of biomedical imaging, which are employed to generate signals or enhance the signal contrast in targeted tissues. In the past decade, MOFs and COFs have been shown great potential for used as imaging agents and have been extensively investigated in this field.
In the past several years, owing to the facile functionalization, diversiform structures and compositions, and large porosities of MOFs, MOF-incorporated imaging techniques are widely used in optical imaging, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) imaging.
COFs have good photostability owing to the long-range crystal domain and eclipsed π-π stacking structure. In addition to, the tunable structure and constituent make it has adjustable fluorescence, functionalized surface chemistry. Therefore, COFs are used as potential agents for fluorescence imaging. Fluorescence imaging is a forceful technology for achieving accurate diagnosis and visualize therapeutic process. Fluorescence imaging is also employed to investigate the functions of biological molecules in an inherent microenvironment on account of its high sensitivity, noninvasiveness, rapid response capability, and real-time performance analysis. Some typical examples of use of COFs for fluorescence imaging are shown in Table 1.
Table 1 Typical examples of using COFs for fluorescence imaging
|TPI-COF||Solvothermal reaction||Two-photon fluorescence imaging|
|TTA-DFP CONs||Microwave irradiation||Bioimaging|
|TpASH-NPHS||Schiff base condensation reaction/Liquid sonication||Two-photon fluorescence imaging|
|Pd NPs/CMC−COF-LZU1||In situ coordination||Colorimetric detection and multicolor imaging|
Fig.1 Two-photon and one-photon fluorescence imaging of TPI-COF incubated cells
Alfa Chemistry has a profound research foundation in the field of biomedical imaging, and our high-quality MOFs and COFs work well in the biomedical imaging. Our professional technology team that can also provide customers various MOFs and COFs design and customization services, no matter what design ideas you have, we will implement them together with you. Alfa Chemistry will serve you with the most abundant experience and the most affordable price. If you have any problems, we will provide technical support for you. If you have special needs, we will develop a unique solution for you. Please don't hesitate to contact us.