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Biocatalysis, which can facilitate biotransformation catalyzed by biomacromolecules and even whole cells, is an indispensable part of catalysis industries. The biocatalysts, commonly referred as enzymes, can reduce the reaction activation energy with unparalleled efficiency, selectivity and specificity. Until now, over 5000 catalytic reactions in different industries benefit from the enzymes-based biocatalysis, which are highly reactive and environmentally friendly. Although enzymes possess unparallel advantages than other catalysts, their poor stability, low recyclability, and difficult recovery procedures in general impede their further utilization in catalysis industries. To circumvent the shortcomings in biocatalysis, a promising strategy has been proposed, namely enzyme immobilization into solid materials. Enzyme immobilization into solid supports not only improves convenient handling and rapid separation but also increases their stability against organic solvents or heat. The critical point about enzyme immobilization is the choice of solid support. MOFs and COFs have unparalleled advantages compared with other conventional solid supports materials such as silica, glass, graphene oxides, carbon nanotubes, polymer microcapsules, and hydrogel attributing to their unique characteristics.
The diversity of building units, molecular-scale tunability, and modular synthetic routes of MOFs greatly expand its ability as the host to integrate with biocatalysts. MOFs can be used as favourable solid supporting materials to immobilize various enzymes to enhance their catalytic activities.
Furthermore, MOFs not only can be excellent supporting materials for enzyme immobilization, but also can be excellent enzyme mimics and stimuli-responsive biocatalysts by themselves, owing to their unique structural properties.
Highly porous and diversity nature of COFs might consider as perfect host materials for enzyme immobilization to improve the desirable properties of enzymes for biocatalysts such as poor stability, low operational range, lack of repeatability, and products/by-products inhibition for large-scale applications. The enzymes can be immobilized into COFs through different techniques, the details are as follows.
Alfa Chemistry provides high-quality MOFs and COFs used in biocatalysis field for enzyme immobilization to improve enzyme catalytic activities. And our professional technology team that can also provide customers with high-quality MOFs and COFs design and customization services, no matter what design ideas you have, we will implement them together with you. In addition, Alfa Chemistry is committed to supporting customers a series of solutions in biocatalytic fields by using MOFs and COFs. Please contact us immediately to order or cooperate in research and development with high quality and reasonable price.